Ozempic and the Obesity Revolution

About this episode

Cardiologist Dr. Naqvi and orthopedic surgeon Dr. Ahmed dive into the obesity drug revolution, explaining how GLP-1 medications like Ozempic, Wegovy, Mounjaro, and Zepbound work on incretin receptors (GLP-1, GIP, amylin, glucagon). They cover the Gila monster origin of exenatide, side effects like nausea and muscle loss (sarcopenia), surgical cancellations from delayed gastric emptying, compounded drug risks, and emerging therapies like retatrutide, oral pills, and once-monthly options.

What we cover in this episode

1. how Ozempic and GLP-1 drugs work
2. difference between Ozempic Wegovy Mounjaro Zepbound
3. Gila monster venom and the discovery of GLP-1 drugs
4. muscle loss and sarcopenia on weight loss drugs
5. GLP-1 drugs and surgery anesthesia risks
6. compounded semaglutide and tirzepatide dangers
7. retatrutide and next-generation obesity medications
8. oral weight loss pills and rebound weight gain
9. GLP-1 drugs for heart failure and fatty liver

Your hosts

Dr. Humayun NaqviPreventive Cardiologist · West Houston Heart Center

Dr. Adil AhmedOrthopedic Surgeon · Baylor College of Medicine

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